Genetic markers associated to improving prolificacy of sheep. A review

Radena Nenova, Ivona Dimitrova, Nevyana Stancheva, Milena Bozhilova-Sakova, Todor Tzonev, Tanya Minkova

Abstract: The application of molecular genetic markers in breeding programs is the basis for the future improvement of existing sheep breeds and preservation of genetic diversity in this animal species. This review aims to survey the literature on genetic markers suitable for inclusion in reproductive control in sheep and in particular to enhance the prolificacy of ewes. In different breeds of sheep, prolificacy can be regulated polygenically or by the action of a major segregating gene from the so-called fecundity genes (Fec). In this review, we focus on the main genes BMP15, GDF9 and BMPR1B belonging to the transforming growth factor-β (TGF-β) superfamily, as well as the gene B4GALNT2 affecting reproduction and in which polymorphisms associated with the emergence of the more prolific phenotype.

Keywords: fecundity genes; prolificacy; reproduction; sheep

Date published: 2023-04-27