Bulgarian Journal of Agricultural Science
Array ( [session_started] => 1720908869 [LANGUAGE] => EN [LEPTON_SESSION] => 1 )


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DMRT3 gene mutation and highly linked SNP in gaitedness horse breeds
Radostina Stoykova-Grigorova, Nadejda Lukanova, Katerina Stefanova
Abstract: The DMRT3 mutation has had a major effect on the diversification of the domestic horse, as the altered gait characteristics of a number of breeds, including this mutation. Doublesex and mab-3 related transcription factor 3 (DMRT3) gene shown that a mutation from cytosine (C) to adenine (A) has a major impact on harness racing performance of different breeds. The DMRT3 mutant allele (A) has been found in high frequency in gaited breeds and breeds bred for harness racing (trot or pace), while other horse breeds were homozygous for the wild-type allele (C). The heterozygous allele (CA) were found in horse breeds for harness racing and four- and five-gaited breeds. Sequncing at SNP BIEC2-620109 resulted in detection of both heterozygous (CT) and homozygous genotypes (CC, TT). Mutation in DMRT3 has a major impact on gaitedness in horses and is presented
at a high frequency in gaited breeds and in horses breed for harness racing. The aim of the study is to describe the effect of the DMRT3 gene mutation and higly linked SNP in different gaited and harness horse breeds.
Keywords: breeds; DMRT3 mutation; gaits; harness; horse
Date published: 2018-08-30
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